Wayne Wakeland

Wayne Wakeland First joined 2000 - Now Title Member Notable works --Fellow, American Production & Inventory Control Society --George C. Hoffman Faculty Excellence Award --Maintaining the PSU Systems Science program through very challenging times Interest in SIGs --Business Logistics & Planning --Biomedical Simulation --Health Policy Modeling & Sim. --Social Ecological Systems --Environmental Sustainability Degree(s) PhD Systems Science Master of Engineering BS Engr Field(s) of study To fill University(ies) Portland State University Harvey Mudd College Specialization(s) --Operations Research --Technological Forecasting & Futures Research --Modeling & Simulation --Systems Practice ORCID 0000-0001-5069-3958 Links [| ORCID Profile]

Wayne Wakeland is Professor and Systems Science Program Chair at Portland State University in Portland, Oregon USA. He graduated from the program in 1977, and worked in industry for the next 25 years in corporate planning, manufacturing, information technology, and product development. He also began developing and teaching graduate Systems Science classes on computer modeling and simulation. In the early 2000’s Wayne began transitioning to fulltime academics, teaching systems methods and doing research on traumatic brain injury, fisheries sustainability, and the opioid crisis. He took on the role of Program Chair in 2013 when George Lendaris retired, working closely with senior faculty member Martin Zwick.

Personal Life

Wayne grew up in Alaska and came to love hiking, camping, and fishing. He also loved to learn. He applied and was accepted into Harvey Mudd College in California. He thought he wanted to be a physicist until his less than stellar mathematical skills were exposed. He then switched to engineering, where linear algebra, differential equations, and computer programming appeared to be sufficient. His focus was on systems engineering and computer simulation. But a career in engineering was not to be. A talk at UCLA by guest speaker Harold Linstone introduced him to Systems Science at PSU, where he matriculated in 1973 and earned his PhD in 1977. He immediately started teaching night classes in computer modeling and simulation at PSU, which have continued to the present.

But his primary work after graduation was as corporate forecaster at Tektronix, where he later became a planning & scheduling manager and then materials manager. He left Tek to work as the manufacturing manager at two spinoffs, Photon Kinetics, and later Magni Systems. He also worked as project manager at Epson America and as IT manager at Leupold & Stevens. But his dual career path became overwhelming, and his primary focus shifted to academia in 2003, and he began developing an externally funded research program leveraging his computer modeling and simulation expertise. He assumed leadership of the Systems Science Program in 2013.

Contributions to Science

Wayne’s research focuses on applying systems science methods, especially system dynamics and agent-based simulation to: (1) recovery from brain injury, (2) prescription drug diversion and abuse, (3) intracranial pressure dynamics, and (4) human stress response and resilience. He has also studied sepsis, cellular receptor dynamics, economic and ecological sustainability, criminal justice system effectiveness, terrorism, and fishery regulation.

1. A vast literature on Recovery from Brain Injury focuses on specific aspects such as acute recovery from severe TBI and, separately, long-term rehabilitation. A systems perspective that considers concussion as a multi-scale complex system resulted in a rich multi-scale conceptual framework [8], a detailed causal loop diagram [5], a demonstration computational model for recovery from brain injury [7], and a targeted lit review [1]
2. Another major public health concern is Prescription Drug Diversion and Abuse, where most prior research had employed statistical models that do not consider the feedback loops in the system. Feedback-oriented policy simulation models were developed and tested to help identify effective policies, most often combinations of interventions that address both supply of and demand for diverted opioid medicines [3, 6, 9, 10]; and support was also provided to another team [2]
3. Intracranial Pressure Dynamics is complex and patient-specific models are sparse. As part of a collaborative effort collecting data on how pediatric patients respond to mild physiological challenges, a comprehensive literature review was carried out [14], a patient-specific computational model was developed [12], and the prediction capability of the model was tested [13]
4. Support was also provided to teams researching Human Stress Response and Resilience, both in adults [11] and children [4]

Selected Publications

• [1] Kenzie E.S., Parks E. L., Carney N., Wakeland W. “System dynamics modeling for traumatic brain injury: Mini-review of applications” Frontiers in Bioengineering and Biotechnology (in press 2022).

• [2] Lim, T. Y., Stringfellow, E. J., Stafford, C. A., DiGennaro, C., Homer, J. B., Wakeland, W., ... & Jalali, M. S. “Modeling the evolution of the US opioid crisis for national policy development” Proceedings of the National Academy of Sciences, 2022 119(23), e2115714119.

• [3] Homer J., Wakeland W. “A dynamic model of the opioid drug epidemic with implications for policy.” American Journal of Drug and Alcohol Abuse. 2021, 47(1) 5-15.

• [4] Christensen J. S., Wild H., Kenzie E. S., Wakeland W., Budding D., Lillas C. “Diverse Autonomic Nervous System Stress Response Patterns in Childhood Sensory Modulation.” Frontiers in Integrative Neuroscience, 2020 Vol 14.

• [5] Kenzie E, S., Parks E.L., Bigler E.D., Wright D.W., Lim M.M., Chesnutt J.C., Hawryluk G. W. J., Gordon W., Wakeland W. “The Dynamics of Concussion: Mapping Pathophysiology, Persistence, and Recovery with Causal-Loop Diagramming” Frontiers in Neurology 2018 vol 9. https://doi.org/10.3389/fneur.2018.00203

• [6] Halvik S., Geissert P., Wakeland W., Hildebran C., Carson J., O’Kane N., Deyo, R. “Opioid Prescribing Continuity and Risky Opioid Prescriptions.” Ann Fam Med Sep/Oct 2018 16(5) 440-2. PMID: 30201641

• [7] Wakeland, W., Kenzie E. “Computational Model for Traumatic Brain Injury.” 36th Int’l System Dynamics Conference, Reykjavik, Iceland, Aug, 2018.

• [8] Kenzie E. S., Parks E. L., Bigler E. D., Lim M. M., Chesnutt J. C., Wakeland W. “Concussion as a Multi-scale Complex System: An interdisciplinary synthesis of current knowledge” Front Neurol. 2017 Sep 28; 8:513. PMID: 29033888, PMCID: PMC5626937

• [9] Wakeland W., Nielsen A., Schmidt T. “Gaining Policy Insight with a System Dynamics Model of Pain Medicine Prescribing, Diversion and Abuse” Systems Research and Behavioral Science. 2016 May; 33(3):400-412.

• [10] Wakeland W., Nielsen A., Geissert P. “Dynamic model of nonmedical opioid use trajectories and potential policy interventions.” American Journal of Drug and Alcohol Abuse. 2015; 41(6):508-18. NIHMS744117, PMID:25982491, PMCID: PMC46857106.

• [11] Oken B.S., Chamine I., Wakeland W. “A systems approach to stress, stressors, and resilience in humans” Behavioural Brain Research, 2015 Apr 1; 282C: 144-154.

• [12] Goldstein B., Tasker R. C., Wakeland W. “From Lundberg to SIM-ICP: computational physiology and modeling intracranial pressure,” Science Translational Medicine. 2012; 4(129):129fs6. PMID: 22496544

• [13] Wakeland W., Agbeko R., Vinecore K., Peters M., Goldstein B., “Assessing the Prediction Potential of a Computer Model of Intracranial Pressure Dynamics,” Critical Care Medicine, Vol. 37, No. 3, 2009, pp 1079-89 PMID: 19237921

• [14] Wakeland W., Goldstein B. A review of physiological simulation models of intracranial pressure dynamics. Computers in biology and medicine. 2008; 38(9):1024-41. PMID: 18760775

Links to relevant pages

Systems Science Webpage: https://www.pdx.edu/systems-science/

Wakeland Webpage: https://www.pdx.edu/systems-science/dr-wayne-wakeland

Wakeland Selected Works: https://works.bepress.com/wayne_wakeland/

Wakeland NCBI: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/51890054/?sort=date&direction=.